Association study of the BDNF gene polymorphism (G196A) with overweight/obesity among women from Northwest of Iran

Abstract Background Obesity is a health problem defined by surplus body fat accumulation and one of the leading causes morbidity mortality. Earlier studies indicated influence brain-derived neurotrophic factor ( BDNF ) molecular alterations in development obesity. One these variations G196A single nucleotide polymorphism (Val66Met; SNP rs6265), which impairs intracellular trafficking reduces secretion BDNF. In this study, we evaluated possible association gene with mass index (BMI) among women from Iranian Azeri Turkish ethnic group. Four hundred eighty-four including 343 obesity or overweight 141 age-sex ethnically matched healthy controls were genotyped for applying polymerase chain reaction-restriction fragment length (PCR–RFLP) method. The BMI was using analysis covariance (ANCOVA), comparison alleles genotypes frequencies between patients (obese and/or participants) carried out logistic regression models. Results Individuals carrying Met-Met genotype have significantly lower mean to those non-Met/Met polymorphisms P = 0.0138). Conclusions Val66Met as an trait has been confirmed Northwest Iran.